Wuse District is the north western part of the city, with the Maitama District to its north and the Central District to its south. The District is numbered Zones 1-8. Wuse Market is Abuja's most popular market (Zone 5). The second most important Post Office in the city is located here.

This district also houses the Sheraton Hotel and Towers (Zone 4), Ibro International hotel, Rockview Hotel, the Nigerian Customs Services Headquarters, the Foreign Affairs Ministry Headquarters (Zone 1) and Federal Road Safety Commission (FRSC).

National Agency for Food and Drugs Administration (NAFDAC) (Zone 7), Wuse General Hospital, and the Nigerian Tourism Development Corporation.

Just as Garki District has Garki II, Wuse has Wuse II. This is distinct from Wuse Zone 2.